Erectile Dysfunction (ED) is caused by a complex interaction between nerves, blood vessels, and hormones. The condition can be triggered by various factors including injury to the penile cavernous nerve, natural aging, and certain chronic diseases such as diabetes.
Scientists are constantly working on new ways to treat ED. Currently, a range of options is available including oral medications, suppositories, injections, and vacuum erection devices.
Oral Medications
Sildenafil, tadalafil, and vardenafil are FDA-approved prescription medications that treat erectile dysfunction. These drugs act by inhibiting phosphodiesterase type 5 (PDE5), which causes blood vessels to dilate resulting in a more robust and longer-lasting erection. These pills work quickly, within 30 minutes in most men, and have minimal side effects. Avanafil, another newer medication that works similarly to tadalafil and Levitra, has also been approved by the FDA.
These PDE5 inhibitors are available in pill form, as well as gels and liquids. They can be taken up to 36 hours before sexual activity. In clinical trials, these medicines have demonstrated a significant improvement in ED and have helped men achieve and maintain erections that last through sexual intercourse.
It’s important to note that these medications should only be used under the supervision of a doctor, and are typically covered by health insurance. Injections are also available, including an intraurethral version of the drug alprostadil, which is injected into the penis through a small syringe. NYU Langone urologists often perform the first injection at their offices to determine how much medication is needed. They then provide patients with the appropriate dosages in vials with syringes to administer at home.
It’s crucial to avoid illegal, off-brand treatments like Kamagra oral jelly, as they aren’t regulated by the FDA and could contain dangerous levels of the active ingredient sildenafil citrate. These unregulated products may interact with nitrates, which are found in many common medications like those for diabetes, high blood pressure, and heart disease.
Injections
Since the early 1980s, self-administered injection therapy has been a successful option for treating ED. Although many men feel uncomfortable thinking about placing a needle into their penis, this treatment is very effective and is often covered by insurance, depending on the exact policy.
This treatment involves injecting medication into the corpora cavernosa via a syringe. This is a great option when oral medications are not working. There are a variety of medications that can be used to treat ED, including papaverine, alprostadil, and Bi-Mix. While these medications are very effective, they can sometimes cause side effects, such as a prolonged erection (priapism). Priapism is not serious, but it should be treated promptly by calling your healthcare provider or going to the emergency room.
Other erectile dysfunction treatments include acoustic shockwave therapy and implantable pumps. These treatments also target corporal cavernosa but are more targeted than oral medications. They have a high success rate and can help restore normal blood flow to the area. They are usually covered by health insurance, but patients should always consult with their urologist to ensure they get the best coverage possible. In addition, these treatments can be combined with PDE5 inhibitors for added benefits.
Devices
As well as prescription-only ED medications and injections, some devices can be used to help men get and maintain an erection during sexual activity. For example, a vacuum constriction device (VCD) works by using an elastic ring that fits around the base of the penis to apply pressure, forcing blood into the area and creating an erection. This type of ring can be especially effective for men who cannot easily obtain and sustain an erection as a result of health conditions such as diabetes, spinal cord injury, prostate cancer treatment, or nitrate drug use.
Unlike the rogue erectile dysfunction medications sold through spam emails and websites, medically approved ED medications like sildenafil have been extensively tested to ensure they are safe and effective for use. However, it is important to remember that buying medication from unauthorized retailers can put you at risk of a range of dangerous side effects.
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It is also a good idea to speak to your doctor about the best treatments for your individual needs. They can advise on a holistic approach that may include the use of medications, a VCD, or other device, as well as recommended lifestyle changes such as improved diet, weight management, exercise, reduced alcohol intake, and stress reduction therapy. In addition, if psychological issues are contributing to your ED, your doctor can refer you for psychotherapy.
Stem Cell Therapy
Stem cells are undifferentiated cells that can develop into specialized cells, such as smooth muscle or endothelial cells. Scientists believe that stem cells can help improve erectile function by promoting the growth of new blood vessels and repairing damaged penile tissue. The stem cells used in therapy are typically extracted from the patient’s body, such as bone marrow or adipose tissue (fat), which reduces the risk of rejection and other adverse reactions.
Researchers have found that mesenchymal stem cells from adipose tissue and bone marrow can stimulate penile tissue regeneration and improve blood flow to the area by secreting growth factors and other chemicals. In addition, researchers have found that phosphodiesterase-5 inhibitors can enhance the effectiveness of stem cell therapy for erectile dysfunction.
Studies utilizing human embryonic stem cells have also shown promising results. Researchers believe that these cells can help regenerate nerves and improve erectile function by differentiating into cavernous smooth muscle and endothelial cells. They may also be able to help treat Peyronie’s disease, a condition that causes fibrous scar formation in the tunica albuginea and can lead to poor erections.
Although the results of these trials are promising, further research is needed to determine long-term safety and efficacy. In addition, it’s important to understand that these treatments are not a substitute for a healthy lifestyle and that you should always consult your physician before trying any type of erectile dysfunction treatment. Read More…
